Proton Spatially Fractionated Radiotherapy or Photon Stereotactic Body Radiotherapy in Combination With Pembrolizumab Before Surgery for the Treatment of Locally Advanced and Radiation-Naive Locoregionally Recurrent Oral Cavity Cancer, OSPRI Trial

​ Conditions: Locally Advanced Oral Cavity Squamous Cell Carcinoma; Locally Recurrent Oral Cavity Squamous Cell Carcinoma; Oral Cavity Squamous Cell Carcinoma

Interventions: Procedure: Biopsy Procedure; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Biological: Pembrolizumab; Radiation: Photon Stereotactic Body Radiation Therapy; Procedure: Positron Emission Tomography; Radiation: Spatially-fractionated Radiation Therapy; Procedure: Surgical Procedure

Sponsors: Mayo Clinic

Not yet recruiting Conditions: Locally Advanced Oral Cavity Squamous Cell Carcinoma; Locally Recurrent Oral Cavity Squamous Cell Carcinoma; Oral Cavity Squamous Cell Carcinoma
Interventions: Procedure: Biopsy Procedure; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Biological: Pembrolizumab; Radiation: Photon Stereotactic Body Radiation Therapy; Procedure: Positron Emission Tomography; Radiation: Spatially-fractionated Radiation Therapy; Procedure: Surgical Procedure
Sponsors: Mayo Clinic
Not yet recruiting