This Study Aims to Improve the Stratification of Patients With Acute Myeloid Leukemia to Enable More Personalized and Effective Treatments, and to Identify and Functionally Validate, at the Single-cell Level, Biomarkers That Can Predict Response to Venetoclax.

​ Conditions: Acute Myeloid Leukemia

Interventions: Genetic: Bulk genotyping of AML samples at diagnosis and relapse, scRNA analysis at diagnosis, scRNAseq and genotyping analysis at day 28 after therapy, spatial transcriptomic analysis at day 0 and 28

Sponsors: Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico; ASST Grande Ospedale Metropolitano Niguarda; AOU S. Orsola Malpighi; Humanitas Clinical and Research Center; A.O. Ospedale Papa Giovanni XXIII; Azienda Ospedaliero-Universitaria di Parma; Ospedale Policlinico San Martino

Recruiting Conditions: Acute Myeloid Leukemia
Interventions: Genetic: Bulk genotyping of AML samples at diagnosis and relapse, scRNA analysis at diagnosis, scRNAseq and genotyping analysis at day 28 after therapy, spatial transcriptomic analysis at day 0 and 28
Sponsors: Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico; ASST Grande Ospedale Metropolitano Niguarda; AOU S. Orsola Malpighi; Humanitas Clinical and Research Center; A.O. Ospedale Papa Giovanni XXIII; Azienda Ospedaliero-Universitaria di Parma; Ospedale Policlinico San Martino
Recruiting