Lymphodepletion With Low Dose Total Body Irradiation Before Standard of Care Tisagenlecleucel for the Treatment of Relapsed and Recurrent Large B-cell Lymphoma

​ Conditions: Recurrent Diffuse Large B-Cell Lymphoma; Refractory Diffuse Large B-Cell Lymphoma

Interventions: Procedure: Biospecimen Collection; Procedure: Computed Tomography; Drug: Cyclophosphamide; Drug: Fludarabine; Procedure: Leukapheresis; Procedure: Positron Emission Tomography; Biological: Tisagenlecleucel; Radiation: Total-Body Irradiation

Sponsors: Nathan Denlinger; Novartis

Not yet recruiting Conditions: Recurrent Diffuse Large B-Cell Lymphoma; Refractory Diffuse Large B-Cell Lymphoma
Interventions: Procedure: Biospecimen Collection; Procedure: Computed Tomography; Drug: Cyclophosphamide; Drug: Fludarabine; Procedure: Leukapheresis; Procedure: Positron Emission Tomography; Biological: Tisagenlecleucel; Radiation: Total-Body Irradiation
Sponsors: Nathan Denlinger; Novartis
Not yet recruiting